Latest Advances of human NLRP1

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creativework.keywordsNLRP1, inflammation, inflammasome, pyroptosis
dc.contributor.advisorDr. Asim Kumar Bepari
dc.contributor.authorFarhin Muntaha Tasnim
dc.contributor.id2125540672
dc.coverage.departmentPharmaceutical Sciences
dc.date.accessioned2025-03-25
dc.date.accessioned2025-03-25T05:48:38Z
dc.date.available2025-03-25T05:48:38Z
dc.date.issued2025-03-25
dc.description.abstractThe human NLRP1 (hNLRP1) gene emerges as a pivotal player in a spectrum of human disorders, spanning from cancer to neurological ailments. Genetic variations within hNLRP1, particularly single nucleotide polymorphisms and several other point mutations, correlate strongly with these disorders, often residing in critical regulatory segments of the gene. These insights into genetic intricacies are instrumental in unravelling hNLRP1's involvement in various diseases and offer prospects for targeted therapeutic interventions. The human NLRP1 is infamous for its duality, providing subtle beneficiary roles in certain conditions when active in regulated levels and while being prominently higher and profound in most disease conditions that involve immune responses by inflammatory mediation, that can vary from autoimmune conditions to chronic disorders such as arthritis and cardiovascular ailments, ascertaining its nuanced nature when interacting with various types of stimuli and conditions. This review sheds light on the illustrative viewpoints of its mechanism of action, the multifaceted roles of NLRP1 in health and disease, and presenting avenues for future research and therapeutic development aimed at harnessing its potential for clinical benefit across diverse pathological contexts.
dc.description.degreeUndergraduate
dc.identifier.urihttps://repository.northsouth.edu/handle/123456789/1077
dc.language.isoen
dc.publisherNorth South University
dc.rights© NSU Library
dc.subjectMEDICINE::Physiology and pharmacology::Pharmacological research::Pharmacology
dc.subjectMEDICINE::Physiology and pharmacology::Pharmacological research::Clinical pharmacology
dc.titleLatest Advances of human NLRP1
dc.typeArticle
oaire.citation.endPage75
oaire.citation.startPage1
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